UPR Biology


Ivette García-Castro

Professor

Ph.D., Catholic University of America, 1973.

Phone: (787)764-0000 ext. 7581, 4884.

Fax. (787) 764-2610

Field of Interest: Oncology: Motile Response of Cancer Cells to Extracellular Matrix Components and Autocrine Motility Factors


Studies to determine the role of arachidonic acid metabolites in the chemotactic and haptotactic response of A2058 human melanoma cells to extracellular matrix components (EMC's) such as fibronectin, laminin and collagen Type IV.

Additional studies include the role of autocrine motility factors secreted by cancer cells on these cells and other cells.

Effects of up-regulators of cadherins in preventing cell motility in response to autocrime motiligy factors, are also investigated. The information obtained will help in understanding the mechanisms which influence cancer metastasis in order to design therapeutic strategies.

Selected Publications: