UPR Biology

Ivette Pérez-Chiesa


Ph.D., University of Chicago, 1970.

Phone: (787)764-0000, x2009

E-mail: yperez@upracd.upr.clu.edu

Fax: (787) 764-3875

Field of Interest: Developmental genetics of Drosophila. Mechanisms of chemical mutagenesis.

One of our projects is to evaluate the mutagenic potential of some anticancer compounds and topoisomerase II inhibitors in somatic and germ cells of Drosophila melanogaster and to relate these findings to their molecular structure. In addition, the effect of several antimutagenic compounds in the genotoxicity of anticancer drugs and other compounds is being evaluated.

Another proyect is the characterization of the alcohol dehydrogenase ADH) gene enzime system in representative species of the cardini group of Drosophila. Our aim is to contribute to the understanding of the evolution of this gene and its regulatory components. The species of this group are distributed in tropical America and the Caribbean. Studies include: determination of alcohol tolerance and enzyme activity; a genetic analysis of the electrophoretic patterns observed for ADH in these species abd their hybrids; ontogeny and tissue-specific exspression.

Major Equipment and Facilities Used: Facilities for the preparation of culture media, cleaning and sterilization of glassware. Drosophila insectary in laboratory with basic equipment; incubators; refrigerators; disecting microscopes (Zeiss, Bausch & Lomb); compound microscopes (American Optical, Zeiss); starch, acrilamide and agarose gel electrophoresis equipment; Laminar Flow Hood (Class II type B).

Selected Publications: